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Unforgivable Defeat the Abstract Daddy.

James of All Trades Kill at least one enemy with Wooden Plank, Steel Pipe, Handgun, Shotgun and Rifle in a single playthrough.

10 level Pass the tenth level

9 level Pass the ninth level

No Big Deal Kill 75 enemies with ranged weapons.
75/75

Into the Abyss Reach the end of the long staircase.

Leftovers Find the pizza in Pete's Bowl-O-Rama.

Level 4-3 Complete Level 4-3

Level 4-2 Complete Level 4-2

Level 4-1 Complete Level 4-1

Level 3-3 Complete Level 3-3

Level 3-2 Complete Level 3-2

Level 3-1 Complete Level 3-1

Level 2-3 Complete Level 2-3

Level 2-2 Complete Level 2-2

Level 2-1 Complete Level 2-1

Level 1-3 Complete Level 1-3

Level 1-2 Complete Level 1-2

Level 1-1 Complete Level 1-1

8 level Pass the eighth level

Skeletal Collapse Have your victim's skeletal system collapse first.

7 level Pass the seventh level

6 level Pass the sixth level

5 level Pass the fifth level

4 level Pass the fourth level

3 level Pass the third level

2 level Pass the second level

1 level Pass the first level

Muscular Collapse Have your victim's muscular system collapse first.

My First Customization Set the recommended module and any accessories for the first time.

Respiratory Collapse Have your victim's respiratory system collapse first.

Alone Again Survive the chase in Brookhaven Hospital.

Renal Collapse Have your victim's renal system collapse first.

Lupus Nephritis Evolve Lupus Nephritis.

Nervous Collapse Have your victim's nervous system collapse first.

Richie Rich Collect 250 Bio Points or more in a game.

Circulatory Collapse Have your victim's circulatory system collapse first.

All-in Unlock all diseases in one system.

Close Call Win a game at 95% recovery or more.

It's Never Lupus Evolve Lupus.

Heart Attack Evolve Heart Attack.

Digestive Collapse Have your victim's digestive system collapse first.

Immune Collapse Have your victim's Immune system collapse first.

Silent Killer Evolve 6 or more diseases before the recovery has started.

Walk In The Park Win a game before the recovery reaches 70%.

My First Practice Hit a combo of 39 in practice for the first time (any difficulty).

Nightmare Fuel Defeat the Flesh Lip.

Blunt Force Trauma Kill 75 enemies with melee weapons.
75/75

Admitted Reach Brookhaven Hospital.

Shattered Destroy 50 windows.
50/50