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Something sticky Beat the Depths 20 times

Spelunker Boy Beat the Caves/Catacombs without taking damage

It Lives Kill Mom's Heart 11 times

Blue Baby Kill Mom's Heart 10 times

A Fetus In A Jar Kill Mom's Heart 9 times

A Quarter Kill Mom's Heart 8 times

Cat Scratch Fever Win ten bets on three-round tournaments at JCC.

Judas Kill Satan

Daemon's Tail Kill Satan with Azazel

Everything Is Terrible Kill Mom's Heart 5 times

The Halo Kill Mom using the Bible

Behind the Masks Complete chapter "Masks"

Told and Retold Complete chapter "Return"

In a Fancy Hotel Complete chapter "Room 665"

A Lunar Challenge Complete a mission in a special sector.

Our Promise Complete the game on any difficulty.

Escape Artist Unlock every escape hatch.

Sentinel Breach Take down the Sentinel.

Minor Deity Defeat the Parasiter on Evil difficulty

The Satanic Bible Kill Isaac with Azazel

All Accounted For Find all weapons for both characters

All His Life Complete chapter "We Sing"

Lights Shining Find the Flare Gun

Yippee Ki-yay Find the Double-Barrelled Shotgun

Stunning Vistas Stun an enemy with a Flashbang

This is the Moment Dodge at the last minute to avoid an enemy attack

Back to Life Use a Coffee Mug Charm to prevent defeat

Repeating Protocols Completed New Game +.

EVE Protocol Acquired all trophies.

Cost of Lost Memories Achieved Cost of Lost Memories ending.

Revenging Agent Defeated 50 enemies in Tachy Mode.
50/50

Transcendence Kill Mom's Heart 3 times

Perfect Physical Enhancement Enhanced HP to its max.
6/6

Return to the Colony Achieved Return to the Colony ending.

Naytiba Researcher Got information on all Naytibas.
67/67

Making New Memories Achieved Making New Memories ending.

Thorough Technician Learned all skills.
96/96

Meticulous Explorer Activated all Camps.
89/89

Raven Defeated Raven.

Perfect Blood Edge Enhanced Blood Edge to its max.
15/15

Demogorgon Defeated Demogorgon.

Karakuri Defeated Karakuri.

Perfect Rechargeable Tumbler Enhanced the Rechargeable Tumbler to its max.
5/5

Perfect Beta Energy Enhancement Enhanced Beta Energy to its max.
6/6

Can Collector Collected all cans.
49/49

Belial Defeated Belial.

Silent Executioner Defeated 50 enemies by execution.
50/50

Relentless Destroyer Defeated 50 enemies with Burst Skills.
50/50

Perfect Exospine Enhanced 10 Exospines to their max.
10/10

Nano Suit Collector Acquired 30 Nano Suits.
30/30