K1tt__

A Secret Exit Complete ??? 3 times

New Area Kill Hush for the first time

Boss Rush Beat the Boss Rush

Broken Ankh Kill Satan with Lazarus

Forget Me Now Kill Satan with ???

The Halo Kill Mom using the Bible

The Lost Finish the game's final secret

Lost Poster Beat the Dark Room with Isaac

Bloody Lust Kill Isaac with Samson

Dark Room Beat the Dark Room

Golden God You are the best!

Mama's Boy Beat the Womb/Utero without taking damage

Blood Rights Kill Satan with Samson

The Negative Beat Sheol 5 times

The Chest Beat the Chest

Eve's Bird Foot Kill Isaac with Eve

Judas' Tongue Kill Satan with Judas

The Relic Kill Isaac with Maggy

The Polaroid Beat Cathedral 5 times

The Guillotine Kill Isaac with Judas

The Bomb Bag Kill Satan with Cain

All's Well That Ends Well Finish the game (with a heartfelt "thank you!" from Larian Studios).

Hero of the Forgotten Realms Save the realms: destroy the Absolute once and for all.

Ceremorphosis Make the ultimate sacrifice: become a mindflayer to defeat the Netherbrain.

Interfectorem Draconis Kill the Red Dragon in the Upper City.

Infernal Jungle Collect 10,000 Aberrant Cinders in Nahantu Helltides.
100/100

End of the First Mother Defeat the Echo of Lilith.
100/100

Kurast Cleanser Complete 25 runs of the Kurast Undercity.
100/100

Wholly Horadric Activate a Charm Set's 5-piece bonus.
100/100

Prepared to Fight Complete 10 War Plans.
100/100

Hatred Banished Complete the Lord of Hatred campaign.
100/100

Skovos Slayer Kill 666 Golems, Merfolk, or Morlu.
100/100

Demonic Dispute Kill 100 enemies with your Demonology skills.
100/100

A Blank Card Kill Isaac with Eden

The Coin Bag Kill Isaac with Cain

Mom's Knife Kill Satan with Isaac

Can I Borrow That? Confuse a certain enemy and borrow its shield.

Can't Stop, Won't Stop Print all obtainable weapons, hacking nodes, and abilities during the main story.

IT'S OVER 6000! Deal 6000 gunshot damage in one second.

The Right Man for the Job Complete Unknown Signal.

You're Not Getting Away That Easy Defeat a Sweeper bot.

A Lunar Challenge Complete a mission in a special sector.

Our Promise Complete the game on any difficulty.

Top-Shelf Item Upgrade a weapon using Pure Lunum.

Escape Artist Unlock every escape hatch.

Sentinel Breach Take down the Sentinel.

Cradle Surveyor Reach 100% sector progress in a sector.

Awakening Fix up Diana.

Mission Unveiled Make it to Nexus Tower.

Replicating Extraordinaire! Complete an REM series.