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Guardian Angel Kill Satan with Maggy

The Relic Kill Isaac with Maggy

The Lost Finish the game's final secret

Eve's Bird Foot Kill Isaac with Eve

Mid Stakes Win a run on at least Black Stake difficulty

The Coin Bag Kill Isaac with Cain

ROI Buy 5 Vouchers by Ante 4

The Book Of Secrets Kill Satan with Eden

I like to live dangerously… Against all odds, you finished the game with the Cursed Sword!

Let's get down to the nitty gritty... four Boss Stem Cells active

Not so tough You slayed 100 elites. Badman.

Harder Better Faster Stronger Finish the game with three Boss Stem Cells active

Deft extraction Absorb your fourth Boss Stem Cell

Ohhhhhh! That hurt! Die while carrying at least 100 cells. Burn.

The dead center of the island... Reach the Graveyard for the first time.

What? There's nothing wrong with these... Finish the game with the starter sword, bow or shield.

Steam rolled. You beat "The Concierge" without taking a single hit!

It rubs the lotion on its skin! Reach the Prison Depths for the first time.

Do you need... A hand?? Bahaha! Beat the Hand of the King without taking a single hit.

The Dance You beat the "Time Keeper" without taking a single hit.

To Charon's Credit Earn a Loyalty Card

Is There No Escape? Clear an escape attempt

Haste of Hermes Get 20% dodge chance with the Lambent Plume

Finished, without fear. Finish the game with two Boss Stem Cells active

Artful extraction Absorb your third Boss Stem Cell

Born sapper You completed the Derelict Distillery without using the Barrel Launcher!

Going down! Kill an enemy with an elevator.

Return to sender You killed an Infected Worker with his own barrel!

Cheers! Reach the Derelict Distillery for the first time!

Don't. Touch. Anything! Reach the Corrupted Prison for the first time.

Up, Guards, and at them again! Finish the game with a Boss Stem Cell active.

Masterful extraction Absorb your second Boss Stem Cell

Welcome to MASTER DUEL Register the player name

The Bank always wins in the end Reach the Bank for the first time.

Incy Wincy… Absorb the Spider's Rune!

Fortune and glory, kid. Fortune and Glory... Reach the Slumbering Sanctuary for the first time!

Is there something in your eye? You beat "Conjunctivius"!

Even the rats avoid the place... Reach the Insufferable Crypt for the first time.

Who needs an Italian plumber? Reach the Ancient Sewers for the first time.

Never fallen Finish the game with "Ygdar Orus Li Ox" in your possesion!

Surgical extraction Absorb your first Boss Stem Cell

The last rampart falls... Beat the Hand of the King.

Bend the knee? I think not… Reach the Guardian's Haven for the first time.

Absolution Be cursed... Survive.

Afraid of the dark? Reach the Forgotten Sepulcher for the first time!

La Brute Absorb the Ram's Rune.

Soap Connoisseur Own all cleaning liquids at the same time

First Steps In the Back Garden, complete all 12 stepping stones first

Starting Out Earn 5 Stars in Career Mode

Arms Collector Unlock each of the Infernal Arms