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It's just a scratch Complete THE TWO COLONELS Chapter without using any Medkits on Normal or higher difficulty.

Escapologist Break out of prison after being arrested - aren't you daring?

Dark Room Beat the Dark Room

Great Owl Find all the Night Hunters' secret stashes in the SAM'S STORY chapter.

Chaos Collector Recover 30 Chaos Gems

Let's Play Complete the first Horde Mode Mission

Pacesetter Completionist Gain all stars in 'Pacesetter'.

Fight With Care, Bear Defeat Ursa Major without taking a punch.

Gemologist Have 10 unused gems in your ship at one time.

The Man who Broke Ties Completed Chapter 8.

100 Yen Clear the Arcade mode on Hard difficulty or higher.

Thorough Researcher Collect all pieces of written information.

Is there a problem? Complete all missions (on Nephilim or above) on Hardcore mode with Dante

One hell of a party! Complete all of the Secret Missions

Shot Through the Heartwood Find a new sword in the the Twilight Garden.

Expert Silversmith Recover all the Void, Chaos and Life gems

BLENDER Find the figurine of Blender

Beware the Words of the Mad... See all of the endings of
Pandemonium of the Oboro Blade.

Speed Slayer Kill the Breeder in less than 5 minutes in Nightfall in Regular or Hardcore difficulty.

Throttled Survival Kill the Breeder while using a Relic in Nightfall in Regular or Hardcore difficulty.

Guardian Angel Kill Satan with Maggy

The Author's Plan Collect all of the forgotten fragments.

Uruku Defeat the Uruku variant.

Velocity Completionist Gain all stars in 'Velocity'.

HYPER FEAT BOY Find the figurine of Hyper Feat Boy

The Jury's Perspective Fulfilled all pacts for Penitence.

Evolution Completionist Gain all stars in 'Evolution'.

A Better Tomorrow Fulfilled all pacts for Recursion.

Sapphire Beat the game with the Defect.

Brick by Useless Brick Solve your problems peacefully

The Dance You beat the "Time Keeper" without taking a single hit.

The Relic Kill Isaac with Maggy

But I Only Have Two Hands! Equip Descent into Misery, The
Threads of Fate, and Oboro
Muramasa.

What Remains of Power Collect all of the Relic Dust.

The path of the warrior Acquire all of the skills and upgrades

Survived Mayday Kill the Kraken for the first time in Mayday in Regular or Hardcore difficulty.

Commanding Awe Completed all Avalon Pacts.

All Roads Lead Find all three portals to the Twilight Garden.

Missile Kiss Make two Power-Metal missiles collide.

Can You Feel It? Defeat The Hand

T.H.R.E.A.T. Eliminated Survive 3 turns in the THREAT Room with every hero.

Just A Pawn Completed Mission 06 in campaign mode.

… and you shall find Find and unlock 110 Drop Zones in Alps

Begone! Free all of the Lost Souls in Vergil's story

A Forged Maestro Destroy two or more Screecher enemies with a controlled Ticker.

The Bomb Bag Kill Satan with Cain

Wishing for the Best Complete the "Last Wish" Raid.

Groceries That's one way to stock your fridge

The Bank always wins in the end Reach the Bank for the first time.

Targets Acquired Get past the first gate in Awakening in Regular or Hardcore difficulty.