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Doctor Cole Heal 250 pedestrians.

Veteran Complete all chapters on Veteran.

Eye Sore Collect 20 Cyclops Eyes

Bond Broken Complete the Game

Chimney Sweep Synchronize every Viewpoint in London.

Steel Fist Master Kill 20 Enemies with a Single Punch After Weakening Them with Gunfire

Head Hunter Use the Precision ability to rack up three head shots in rapid succession.

Light as a Feather Collect all of the Phoenix Feathers

Street Sweeping Conquer all the boroughs in London

Fully Researched Spider Splicer The player has fully researched the Spider Splicer

Master Fortune Hunter Find 100 Treasures

Cosplay Kill an Enemy While Playing as an Alternate Character Costume Other Than Drake

Nemesis Down Cause Nemesis to relinquish an item.

Master Thief Collection Find all Treasures and the Strange Relic

Artisan Craft a Level 10 Item.

The Eyes have It Collect all of the Gorgon Eyes

You're so Sly Collect all Dead Drops in the Historic District.

It’s getting hot in here... Burn 100 enemies with the Bow of Apollo

Platinum Earn all Uncharted: Drake's Fortune™ Remastered Trophies

Stockpile Obtain all available weapons.

The War at Home Complete the World War I simulation.

He's Gonna Need a Sturgeon Hit 3 Enemies with Fish in the Market

Vehicular Manslaughter Defeat 25 enemies by throwing cars at them.

Thunder Flop Thunder drop from the highest place in New Marais.

Dyno-Might Master Kill 5 Enemies with 1 Explosion

Gotcha! Defeat Stage 2 G using the crane only once.

Mountaineer Climb to the top of the 3 tallest buildings in New Marais.

They Belong in a Museum Obtain all treasures in the game.

Multitalented Acquire ten Perks.

Prolific Photographer Take at least one photo in every research group

Evil Train Bad guys make it clear who the boss is.

Further Down the Rabbit Hole Collect all Dead Drops in the Warren.

Dealt with every Little Sister The player has either Harvested or Rescued every possible Little Sister

Souled Out Summon every Soul with the Claws of Hades

Cole' Blooded Defeat 100 civilians.

Treasure Hunter Complete ten Raids of any type with Jacob or Evie.

A Broad Base Reach Loyalty level 1 with all Associates.

I’ll Take the Physical Challenge Complete the Challenge of the Gods

Master of Pyrotechnics In the Main Campaign, killed 20 enemies with the Barnstormer RPG.

Hotfoot Travel 25 kilometers while riding the rails.

Furious Destroy twenty vehicles by ramming them.

A Quarter-Furlong at a Time Finish first in 3 different Street Races.

Cheat Hard to Cheat Harder Activate a Tweak

The Wings of Angels Be airborne during Supernatural Jumps or Flight for a combined 10 minutes of gameplay

Tragedy in Europe Complete Chapter 2 in Chris' campaign.

Keys to the City Acquire all of the Gang Upgrades.

Oh, You've Done This Before Take down 50 enemies by sticking them with a grenade.

Speed of Jason McDonald Beat the game in under 5 hours on any Difficulty

Obedience School Deliver 50 kicks to Hounds

Zombie Roundup Kill 3 enemies at once with a sub-weapon.