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Isaac's Heart Kill Isaac with The Lost

Say Hello To My Little Friend Destroy 15 Tanks.

It's The Final Countdown Complete all Main Missions.

The Mind Kill Satan with The Lost

Challenges Beat all Challenges

Fashionista Collect 200 items of apparel.

Yippee-Ki-Yay Destroy 15 Harvesters.

Postgraduate Have two separate characters with different active specializations.

Bag of Tricks Kill the Vendor Mimic.

Sky Fall Reach the Fractured Shrines for the first time.

Go play outside! Reach the Arboretum for the first time.

Shots Fired Deal 1000 damage to ARC enemies.
382/1000

It's Over 9000! Inflict over 9,000 damage without breaking the chain meter.

Engineer Collect all machine blueprints.

Tourist Collect all souvenirs.

Gardener Collect all garden gnomes.

DJ Collect all mixtapes.

The mud is getting warm, so you might as well swim. Reach the Morass of the Banished for the first time.

Monster Combo Complete a 50-chain combo.

URBAN DEMOLISHER Destroy 1000 Base buildings.

Lilith Beat Greed Mode with Azazel

You dig Reach the Cavern for the first time.

Monster hunter Kill 60 creatures.

Born sapper You completed the Derelict Distillery without using the Barrel Launcher!

Analysis Complete Eliminate Thirteen Darknesses in the datascape.

GALAXY CREATOR Create 8 custom planets in the level editor.

Platinum God Collect all items and unlock all secrets and endings

Generation Zero Collect every trophy

Hot and cold Reach the Guardian's Haven for the first time.

Knee deep in mud... Reach the Nest for the first time.

Real Platinum God 100% the game

Size doesn't matter You beat "The Giant"!

Platinum Obtain all trophies

I've got my eyes on you... You beat "Mama Tick"!

Lightweight Knock out 50 humanoids

Adapt and Evolve Destroy one of each Apocalypse Class machine: Tick, Runner, Hunter and Tank.

Am I still on the island? Reach the Castle's Outskirts for the first time.

Bound for Hell Sacrifice the Mushroom Boi.

Styricaem's Savior Complete the first act.

Manticore Mauler Trigger break mode while fighting the Manticore.

CHALLENGE CREATOR Create planets with all the gameplay types in the level editor.

Trapped Trapper Trap an enemy using the Fractured Shrines environment!

Oh how fast they grow! Get the Leghugger to evolve

Beyond the Curtain Defeat Yozora.

Into the vampire's den Reach Dracula's Castle for the first time.

Middleweight Knock out 100 humanoids

A Tense Danmaku Match Both players entered the “Extend” state in a match.

Iceberg right ahead! Reach the Shipwreck for the first time!

Raider Ransack 40 chests.

Don't fear the Reaper Reach the Defiled Necropolis for the first time.