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Vigorous Opposition In the Main Campaign, killed 75 enemies either with a Vigor or while the enemy is under the effects of a Vigor.

The White Wizard Lift Lady Marwen's curse.

Fully Researched Gun Splicer The player has fully researched the Leadhead Splicer

All Dressed Up Purchase all available alternative costumes in Bonus Features.

Memories of Eregion Activate all Forge Towers.

No Rest for the Weary Stab an injured crawling enemy.

Should Auld Acquaintance... Unlocked 1999 Mode.

Express Elevator Ascend 50 vertical launch poles.

Elemental Thief Collect the Crossblade

Incorruptible Earn full positive Karma.

Fight the Good Fight Unlock the good ending.

Ammo Inventor The player has successfully invented all possible ammo types

A Waist of Space Expand inventory slots to max.

Cainhurst Gain entry to Cainhurst, the lost and ruined castle.

Micolash, Host of the Nightmare Defeat Micolash, Host of the Nightmare.

Matching Set Unlock and purchase a power of each type by performing stunts.

Fully Researched Thug Splicer The player has fully researched the Thuggish Splicer

For My Brother Kill the Great White Graug.

Return to Sender Send a Helicopter's rockets back at it using any Blast ability.

Chalice of Ailing Loran Acquire the Chalice of Ailing Loran that seals
the tragic land lost to the sands.

Amygdala Defeat Great One: Amygdala.

Hero to the People Stop 80 crimes in progress.

Dazed and Defused Take down the Blast Shard Bomber.

Mergo's Wet Nurse Defeat Great One: Mergo's Wet Nurse.

Nothing Can Bring Me Down Stay off the ground for 130 meters.

The Grave Will Out the Truth Uncover the secret in the old house.

Blood in the Streets Completed Emporia.

The Choir Gain entry to the realm of the Choir,
the high stratum of the Healing Church.

Street Sweeper In the Main Campaign, killed 50 enemies with the Founder China Broom Shotgun or Vox Heater.

Beyond Hope Save Lithariel's life.

Get Over Here! Rope pull 5 enemies off edges.

Maxed All Tracks Purchased every slot in all four Plasmid and Tonic tracks

Higher Learning Completed Comstock House.

Divide and Conquer Eliminate the bodyguards of two Warchiefs, then draw them out and kill them.

Entrapment Catch a player in a snare trap in multiplayer.

Martyr Logarius Defeat Martyr Logarius.

Celestial Emissary Defeat Great One: Celestial Emissary.

Veteran Complete all chapters on Veteran.

On a Clear Day... In the Main Campaign, killed 30 enemies with the Bird's Eye Sniper Rifle.

Four Fully Upgraded Weapons Fully upgrade four weapons

Fully Researched Spider Splicer The player has fully researched the Spider Splicer

Little Sister Savior The player has completed the game without harvesting any Little Sisters

Hide and Seek Complete Sherry's segment.

Desperate Measures Corner Zakhaev's Son.

Head Hunter Use the Precision ability to rack up three head shots in rapid succession.

A New Master Brand a Captain while in combat.

You're so Sly Collect all Dead Drops in the Historic District.

Ebrietas, Daughter of the Cosmos Defeat Great One: Ebrietas, Daughter of the Cosmos.

Chalice of Isz Acquire the Great Chalice of Isz that seals
the home of the cosmic kin.

Weapon Master Acquire a weapon of the highest level.