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Blood Bank Kill 10,000 enemies

Dark Room Beat the Dark Room

Doublecrossed Eliminate GRIFTER.

Lucky Stiff Found Lucky Montoya's body.

Regenerate Help Sozo.

Pursuit of Knowledge Filled 80% of the Datalog.

Forever Marked Progress the story to unlock.

Steal the Show Perform with the Dead Band at the Mariachi Club as El Muñeco

Body Builder Defeat a Giant Skeleton as Uay Pek's Head

Guardian Angel Kill Satan with Maggy

Why won't it work?! Try using a secondary weapon without having sufficient energy.
2/3

The Relic Kill Isaac with Maggy

Rare and Exceptional Purchase Armor, a Charm, or Vanity Gear from Masujiro the Melodious in New Game+.

Standard Maestro Clear all songs on Standard.

Mutt And Jeff Asked a companion to be the Bad Inspector.

The Bomb Bag Kill Satan with Cain

I was frozen today Complete Crystal Mountain in arcade mode on any difficulty

Friends with Death Die 100 times

Red Kill 100 Red Dudes with a rifle.

Here's Your Order Destroy 4 enemies with a single blast of Sir Galahad's Arc Rifle

Kerouac Has Nothing on You! Take down all of the barriers
blocking the main road.

Extracurricular Beat any bonus level

Finish Him! Eliminate SCORPION.

Full House Complete a Six-player game

Range of Fire Fire 7 different charged attacks in a single level

Beware the Words of the Mad... See all of the endings of
Pandemonium of the Oboro Blade.

Perfect Attendance Play Smart As on 100 different dates

Bested Eelagon! Defeated Eelagon without taking damage.

Cloud Nine Eliminate all High Value Targets.

Breakdance Broker Got the liberty kids to bust a move

Can You Feel It? Defeat The Hand

The Guillotine Kill Isaac with Judas

Blast From the Past Find an homage to what has come before...

The Chosen Bun Win three games as the Hotdog Man character

Enemy Breaker Defeat 50,000 enemies.

Master Play fifteen games

Golden God You are the best!

But I Only Have Two Hands! Equip Descent into Misery, The
Threads of Fate, and Oboro
Muramasa.

Treasure Hunter Find 100 treasure chests.

Shot Through the Heartwood Find a new sword in the the Twilight Garden.

Family Reunion Achieved a compromise between Olivia and Minnie.

Jaguar's Redemption Defeat Salvador as Jaguar

The Coin Bag Kill Isaac with Cain

Judas' Tongue Kill Satan with Judas

Item Hunter Obtain 10,000 items from Music Stages.

Standard Chain Master Clear 50 songs with a Full Chain on Standard.

All Roads Lead Find all three portals to the Twilight Garden.

The Author's Plan Collect all of the forgotten fragments.

Special P.E.T. Benefits Acquired Special Delivery, P.E.T., and Employee Benefits.

Infinity Defeat Dr. Infinity