Isaclon

High Score Score 800,000 points in one game -- with Game Settings set to Hardcore.

Act 3 Cleaner Complete all Act 3 maps on Nightmare difficulty.

A Blank Card Kill Isaac with Eden

Barely Made It Jump over a Cultist Bear Trap without triggering it.

Reaper Defeated the Harvester ("The Golems of Amgarrak" downloadable content)

Catalog Conqueror STU: Complete all nekomata jobs in "The Spider's Thread" mode.

Shelf Promotion Fill your career trophy cabinet

Extract The Data... Get the data that Pritchard is after from within the Palisade Blade.

Expose The Truth! Decide what to do with the evidence you uncovered.

Choppy Chop Chop up 50 bodies

1-Upsmanship Complete Extra Life Mode with 5 Extra Lives in your Inventory (Ancient Gods 1)

Fully Automatic Hit the same driver three times with a 3x Ricochet Bubble

Unexpected encounter Leave Misty Bridge with Colonel Blake

141 Ready Complete the campaign on Veteran

Be prepared Fill the water bottle before leaving base camp.

King of Bling Earn ALL of the Clear Gems

The Book Of Secrets Kill Satan with Eden

No Mo' Modi Get out of jail, but not for free

The super resistant Find the poster of the super resistant.

Upsetting discovery Leave the cemetery.

The letter Retrieve Dana's letter from the automaton.

Grief accomplished Get on board for a new destination.

Maniac Get an S-Rank on all stages on Hard difficulty or higher.

Annihilation Get 100 Elite Zombie Eliminations in Zombies

Just Take the Pod Complete all New Horizon Expeditions.
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Lazarus' Rags Kill Isaac with Lazarus

Reinvent the Weapon Wheel Re-collect all of the weapons on the Weapon Wheel

Career 100% Complete 30 different championships in your career

Cloak and Dagger Met secretly with the agent of the Divine. ("The Exiled Prince" downloadable content)

Relics of the Old Faith Collect all Relics.

Bleeding Knuckles Reach a lifetime score of 5,000,000.

Where is her bedroom? Find all the photos in the Roze's home.

Dipped in Gold Purchase all Safehouse and Player Upgrades in Campaign

Clean Sweep Complete the System Rift Jensen Story without killing anyone.

Trophy Triumphant Acquire all trophies.

Bronze Time Earn a bronze Time Trial record on all tracks

Overachiever Watch the 100% bonus ending

gnilB fo gniK Earn ALL N. Verted Gems

Broken Ankh Kill Satan with Lazarus

A Just Cause Decide what to do with the Altered Biocell.

Cartographer Find all the points of interest in the cemetery.

Art critic Choose one of Leon's paintings and see it years later with Dana.

Eve's Bird Foot Kill Isaac with Eve

Silver Time Earn a silver Time Trial record on all tracks

May Your Death Be Swift Win a Daily Run of No Return on Grounded difficulty

Murder He Wrote Find all pieces of evidence behind the Saridakis murder.

Queen Firefly Kill 15 enemies with Marlene's assault rifle in one encounter in No Return
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Live Die Reload Complete Extra Life Mode with 5 Extra Lives in your Inventory (Ancient Gods 2)

You Shall Pass Acquire a Reward from the Bridge Warden

Master of Elements Acquire the Invoker Archetype