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Master of the reliquary Gather all the fingers of Frankenstein

Untouchable Complete a whole chapter without dying and using a shrine

Wired Up Place 100 wires.

Ladies Night Beat an Echo Six Expansion Pack mission with the 3 female characters in your party.

Basic Instinct Kill the assassin at the docks in Chapter 3 as Caddoc

Thanatophobia WITHOUT using the Architect, complete the game dying 15 times or less

Reign Supreme Defeat a Queen Crawler (Hell on Earth)

Forgive me, sensei Kill Sanjuro Demon without getting hit

Oh Yeah!!! Complete Nothing is as it Seems

I came in like a Resogun Accumulate a total Wrecking combo of 1,000 in Demolition mode

Skirmish - Chapter XIV Finish the levels from Chapter XIV in Squire difficulty

Chimerical Cure Defeat the Chimera (Hell on Earth)

That woman is a demon! Kill Aiko Demon without getting hit

Falcon and the Snowman Complete Crime and Punishment in Single Player.

Two for One Complete Crime and Punishment in Multiplayer.

Thirty is Something Reach Level 30 with any Specialist

Prime Directive Shatter Skeletron Prime.

Appease the Volcano Gods An NPC is destined to die in a trial by fire.

Not on My Watch Kill a fleeing Wargar in the town of Dyfed

The mail always gets through Become the Post Master

Views From the Abyss STU: Complete "The Spider's Thread" mode.

Lightning Emissary Reach the end of the game in 5 hours or less.

Artful extraction Absorb your third Boss Stem Cell

Finished, without fear. Finish the game with two Boss Stem Cells active

Hard pressed Complete all levels on Hard

Dedicated Collector Collect all Upgrades

Spreading Spores Complete Rinri's quest

Exorcist As Caddoc, send the demon in the library back to hell at the end of Chapter 4

Bloody Lust Kill Isaac with Samson

Don't make me pull the trigger! Survive for 5 minutes in Demolition mode

Real Estate Agent Have all possible town NPCs living in your world.

Loyal Customer Purchased all upgrades in the Motor Forge

Under the Radar Select a Starting Location and use an Informant to smuggle an item into Milton-Fitzpatrick.

A Blank Card Kill Isaac with Eden

Monkey Obsessed! Collect every Monkey Toy in the game.

Master Banishers Unlock all trophies

The Postman Delivered the journal to Lucien.

Grounded As Caddoc, Put down the Blind Dragon at the conclusion of Chapter 5

Inferno Adept Collect all Inferno spells.
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Peak Performance Get a score above 1,000,000 points on The Last Yardbird.

Reaper Defeated the Harvester ("The Golems of Amgarrak" downloadable content)

Unbowed, Unbent, Unbroken Complete the game in Ronin mode

A ball for every occasion Try every ball style

Voices From Beyond Unlock all songs in the Mouth of Metal

The Book Of Secrets Kill Satan with Eden

That's a big backpack! Collect every ability upgrade

Trinket Collector Collect all rings and pendants.
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The Spider's shadow Complete a Noir level without triggering an alarm

Lazarus' Rags Kill Isaac with Lazarus

I Come in Peace Slap every alien creature at least once. I suppose that counts as "first contact".