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The Ultimate Sacrifice In Zetsubou No Shima, retrieve the Skull of Nan Sapwe.

Bloody Lust Kill Isaac with Samson

Down We Go (II) Clear Floor 8 of the Spiral Abyss.

Kill 250 Enemies Kill 250 Enemies
0/100

A Blank Card Kill Isaac with Eden

Escaped Awakening Escape Awakening for the first time in Regular or Hardcore difficulty.

Act 3 Cleaner Complete all Act 3 maps on Nightmare difficulty.

Rock, Paper, Plasma In Voyage of Despair, kill 9 zombies via Catalytic Detonations in a single game

Barely Made It Jump over a Cultist Bear Trap without triggering it.

Don't Get Cocky Win a Vaultlanders battle.

Hard Headed Collect 1000 helmets

Round the Riverbend Find the Secret in Blood Stream.

Virus Victory Win a game with Virus on Normal Difficulty or higher

Cook Cook 10 different recipes.

Egg-stra Awakening! Complete the Egg-Stra XP challenge and then scan an obelisk in the Invasion DLC package.

141 Ready Complete the campaign on Veteran

The Book Of Secrets Kill Satan with Eden

Spirited Sparring Kill 500 enemies with Ultimate Skills as a Spiritborn.
0/100

CMISRS Asset Return 39 pieces of intel on a single character.
79/100

No Mo' Modi Get out of jail, but not for free

Shard Snatchers Complete Episode 2.

Lazarus' Rags Kill Isaac with Lazarus

Nightfall Completionist Complete all challenges and kill the Breeder in Nightfall in Regular or Hardcore difficulty.

Annihilation Get 100 Elite Zombie Eliminations in Zombies

Turnabout is Fair Play Kill 50 Cryptids with the Venom-X weapon in Nightfall in Regular or Hardcore difficulty.

Going Up… In The Darkest Shore, unlock the Ubersprengen.

Rock-Steady Treasure Hunter (III) Open 800 chests in Liyue (The Chasm and Chenyu Vale are counted separately).

Tier One In a group of 4 finish an Operation on Challenge with 5 directives enabled.

Feet on the Ground Achieve 100 kills as Footman
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I am death incarnate! Beat the game on "I am death incarnate!" difficulty or higher

Me Gold! Dig up a buried treasure. [Bedrock Only]

Deus Vult Achieve 100 kills as Knight
0/100

Dipped in Gold Purchase all Safehouse and Player Upgrades in Campaign

It's a Trap! In Shi No Numa, kill at least one zombie with three different traps in a single round.

Broken Ankh Kill Satan with Lazarus

Force Majeure Claws Kill a Slasher with Iron Claws.

Controlled Chaos In Revelations, override all of the Corruption Engines before round 6.

Eve's Bird Foot Kill Isaac with Eve

Enter the Hall Reach the Carnage Hall

Upping the Ante Kill the Kraken using a Relic in Mayday in Regular or Hardcore difficulty.

STALKERs delight Cause a nuclear meltdown

Not One Inch In Gorod Krovi, complete a Lockdown Event.

Abyss: Abyssal Crusader Obtain all Abyssal Stars in the Spiral Abyss.

Kraken Unfettered In Voyage of Despair, kill 9 enemies with a single shot of the Kraken

Back From The Dead Reclaim your gear from a Tombstone in MWZ

Cyberized Research all Augments for 10 Items in Zombies

You Rich Now! Get the money from Sink or Swim.

Lost Poster Beat the Dark Room with Isaac

No Such Thing as Too Many Find and use all Armaments in Open Combat Missions

Hat Trick Kill 3 aliens with a single shot from the NX-1 Disruptor in Regular or Hardcore difficulty.