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Phantom Exterminator Kill 5 Phantoms in one game in Nightfall in Regular or Hardcore difficulty.

Act 4 Veteran Complete Act 4 on Veteran difficulty or higher.

Nemesis Meet Skullface

Best Friends Reach a 10-heart friend level with someone.

Hatred Purged Complete the Vessel of Hatred campaign.
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Come Up For Air Reach the top deck in Mayday in Regular or Hardcore difficulty.

Dark Boy Beat the Depths/Necropolis without taking damage

Quick Off Your Feet In Der Eisendrache, wall buy the BRM.

Bye-Bye, Dark Aether Help the lost scientist complete his experiment

The Eagle has Landers In Ascension, escape on all three lunar landers.

Mama's Boy Beat the Womb/Utero without taking damage

Kill 100 Enemies Kill 100 Enemies
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Floater Parachute off a Gantry Crane onto the roof of the Harbormaster's Building in 'Precious Cargo'

Act 3 Veteran Complete all Act 3 maps on Veteran difficulty or higher.

Living Large Upgrade your house to the maximum size.

Hired Gun Complete 20 Contracts in MWZ

Cliques Reach a 5-heart friend level with 4 people.

Abomination Domination Complete Overgrown Temple on Adventure or Apocalypse difficulty.

The Polaroid Beat Cathedral 5 times

Millionaire Earn 1,000,000g

Long Shot Discover the Projectile Vomiting combo

Rush Hour Get a Double Kill with the RC-XD in Multiplayer

Knuckle Sandwich Kill a Deadite with your bare hands

Brainzzzz Discover the Waking Dead combo

Washington Raiders Complete the full Operation Dark Hours raid in a group of eight players.

Death From Above In Der Eisendrache, kill a zombie while being flung by a Wundersphere.

Submerged Mystery Capture a mysterious creature lurking beneath the water's surface.

Smoke And Mirrors, But Without The Mirrors Use a Smoke Grenade to become hidden while at Critical Health.

Deforestation Kill 15 Seeder Turrets in one game in Mayday in Regular or Hardcore difficulty.

Betrayal Kill an enemy from behind at close range while disguised by the Sleeper Agent

That’s a lot of Jigawatts! In Der Eisendrache, electrocute 121 zombies.

The Negative Beat Sheol 5 times

Got All I Need Complete a mission without using aid kits, ammo crates, or consumables.

Write Off Kill 500 Enemies using an Insured Weapon in MWZ

Battle Of The Bastards Kill an enemy wielding a bastard sword, with a bastard sword

Frequent Flyer BASE jump and travel more than 150 m with your parachute

To Know Your Enemy... Get 100 Kills while using Mutant Injections in Zombies

Deft Digger Capture a creature that loves to dig holes in the ground.

First Blood Finish a round of Last Stand

Isaac's Tears Kill Isaac with Isaac

Egg-stra XP! Complete the Egg-Stra XP challenge and then destroy a hive in the Onslaught DLC package.

Survival Skills Complete Dingy Jungle without using a healing potion or losing a life.

Swimming with the Fishes In Voyage of Despair, kill 50 zombies that are underwater in a single game

Master of Masters Reach master rank 200.

Chill Out Defeat 5 mobs with a single Ice Wand attack.

Pandamonium Complete the Panda Plateau secret mission.

Continental Explorer: Land of Surging Thunder Light up the Narukami Island, Kannazuka, and Yashiori Island areas of the Inazuma map.

Think She'll Notice? Destroy all of the cars in the mansion garage in 'Oligarch'

Fling Me to the Moon In Der Eisendrache, use every Wundersphere twice.

Have You Tried Turning it Off and On? Use a Shock Stick to disable an enemy Sentry Gun